Red Sox ace Jon Lester entered the game with 10 career wins against the Blue Jays.
Mike Aviles singed in the third inning and came around to score on a Jacoby Ellsbury base knock to give Boston a 1-0 lead.
Dustin Pedroia fouls one off in the third but would eventually strike out swinging.
Eric Thames led off the home half of the third with a single and was able to advance to second on a wild pitch.
Rajai Davis would score Thames with an RBI triple to right to tie the game at 1-1.
Yunel Escobar lifts a sacrifice fly to right to score Davis and give Toronto a 2-1 lead.
Jays ace Ricky Romero settled into a groove by retiring 17 straight batters after Ellsbury's RBI single.
Jays third baseman Brett Lawrie helped Romero keep the Red Sox off the bases after robbing Cody Ross with a diving catch to lead off the fifth inning. Here, he retires Kelly Shoppach to end the fifth.
Rajai Davis shows his displeasure after being called out on strikes on an appeal by the first base umpire to end the home half of the fifth.
Jose Bautista spikes his batting helmet in frustration after being called out on strikes to end the sixth inning.